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Computational Neurology Lab
Nuffield Department of Clinical Neurosciences, Oxford
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Contact Us

  • Email
    sanjay.manohar@ndcn.ox.ac.uk
  • Address
    Nuffield Department of Clinical Neurosciences
    University of Oxford
    Level 6 West Wing
    John Radcliffe Hospital
    OX3 9DU

University website

https://www.ndcn.ox.ac.uk/team/sanjay-manohar

Google Scholar page

https://scholar.google.co.uk/citations?user=Q5oQw4MAAAAJ

Recent work

  • Neurons that rapidly change their selectivity
    The activity of neurons carries information because they become active only in particular situations. This is called ‘selectivity’, and it allows a group of neurons to signal the state of the world. We may remember things either by keeping neurons active, or by changing their selectivities. However, we haven’t really worked out how changing a neuron’s selectivity works, to help us perform tasks. Here in Bocincova et al. PNAS (2022) (free) we find that neurons in […]
  • What does the claustrum do?
    Here with colleagues from physiology, we review the clinical effects of damage to the claustrum in Atilgan et al. Brain (2022). The claustrum is a thin sheet of neurons in the frontal lobe. Very few reported cases have isolated claustrum damage. In those who did, the findings don’t clearly reflect what you might expect, given the known fMRI activations and connections of the claustrum. […]
  • Hunger increases reinforcement learning rate
    Sometimes we plan ahead, thinking about future consequences of our actions. Other times, we select actions based only on their immediate reward associations. Planning ahead is crucial to staying healthy, but might be affected by motivation. We asked whether hunger affects planned vs directly reinforced action (van Swieten, Bogacz & Manohar Cogn. Aff. Beh. Neurosci. 2021). We found that people learned quicker about action values when they were hungry. Hunger didn’t affect planning. […]
  • Frontal brain damage makes decisions less biased
    Learning from reinforcement is a classic way to study how brain areas contribute to adaptive behaviour. The most frontal parts of the brain probably contribute at a very high, abstract level. In this study (Manohar et al. Cortex 2021), we asked how confident people are in what they have learned. Underside of a human brain showing a part of the ventromedial prefrontal cortex. Healthy people are biased by previous choices, and by competing information, when making these […]
  • Drugs affect subtypes of Parkinson’s disease differently
    In this commentary, I discuss the implications of new work from Hanneke Den Ouden’s lab. The authors subdivided Parkinson’s disease patients into those with and without tremor, and found that learning was affected by dopamine in opposite directions in the two groups! […]
  • Parkinson’s medication has opposite effects on two kinds of motivation
    Patients with Parkinson’s disease lack the brain chemical dopamine. Dopamine is thought to signal upcoming rewards, and this might explain why patients on treatment can develop impulse control disorders. My lab is studying two different ways to motivate people. One way is to reward or punish them based on how well they do — like performance-related pay. The other way is to promise a guaranteed reward, which also tends to keep people motivated (even though they don’t have to). […]
  • Are working memory and visual search windows into the same neural process?
    When you recall an item from memory, a prompt usually brings associated parts of that item into mind. Could this process be the same thing that occurs when you search for a visual target? We tested a neural model designed to perform working memory tasks, to see if it could also perform visual search. The model retrieves information when a partial cue re-activates a pattern of neurons by associative pattern completion. This same process could occur when we look for an item that we have in mind: […]