Our group aims to apply computational neuroscience to clinical neurology.

Our integrative approach
- We try to break cognition down into its elementary computational steps, asking what quantities the healthy brain must be using
- Then we try to understand how these steps map on to brain areas and chemicals, e.g. using brain imaging (fMRI, EEG and MEG)
- Next we study how neurological diseases, such as stroke or dementia, can disrupt cognition. This needs detailed, quantitative characterisation of the clinical problem by studying how patients perform carefully designed tasks.
- Finally, we ask whether medications can modify cognition. We are particularly interested in the motivational effects of dopamine and acetylcholine.
Publications
Pubmed (sorted by year)
2020. A new toolbox to distinguish the sources of spatial memory error.  J Vis 20(13):6
,2020. Dopamine promotes instrumental motivation, but reduces reward-related vigour.  Elife 9.
,2020. Different patterns of short-term memory deficit in Alzheimer's disease, Parkinson's disease and subjective cognitive impairment.  Cortex 132:41-50
,2020. Reward-Based Improvements in Motor Control Are Driven by Multiple Error-Reducing Mechanisms.  J Neurosci 40(18):3604-3620
,2020. Tremor in Parkinson's disease inverts the effect of dopamine on reinforcement.  Brain 143(11):3178-3180
,2019. The psychopathology of NMDAR-antibody encephalitis in adults: a systematic review and phenotypic analysis of individual patient data.  Lancet Psychiatry 6(3):235-246
,2019. Recall cues interfere with retrieval from visuospatial working memory.  Br J Psychol 110(2):288-305
,2019. Dopamine guides competition for cognitive control: Common effects of haloperidol on working memory and response conflict.  Cortex 113:156-168
,2019. Motivation dynamically increases noise resistance by internal feedback during movement.  Neuropsychologia 123:19-29
,2019. Neural mechanisms of attending to items in working memory.  Neurosci Biobehav Rev 101:1-12
,2019. Identification of Myocardial Disarray in Patients With Hypertrophic Cardiomyopathy and Ventricular Arrhythmias.  J Am Coll Cardiol 73(20):2493-2502
,2019. Hippocampal volume across age: Nomograms derived from over 19,700 people in UK Biobank.  Neuroimage Clin 23:101904
,2019. Dopamine D2 receptor stimulation modulates the balance between ignoring and updating according to baseline working memory ability.  J Psychopharmacol 33(10):1254-1263
,2019. Modulation of the pupillary response by the content of visual working memory.  Proc Natl Acad Sci U S A 116(45):22802-22810
,2018. Ignoring versus updating in working memory reveal differential roles of attention and feature binding.  Cortex 107:50-63
,2017. Dopamine Alters the Fidelity of Working Memory Representations according to Attentional Demands.  J Cogn Neurosci 29(4):728-738
,2017. Distinct Motivational Effects of Contingent and Noncontingent Rewards.  Psychol Sci 28(7):1016-1026
,2017. Cortical areas needed for choosing actions based on desires.  Brain 140(6):1539-1542
,2017. Magnetic Oculomotor Prosthetics for Acquired Nystagmus.  Ophthalmology 124(10):1556-1564
,2017. Short-term memory for spatial, sequential and duration information.  Curr Opin Behav Sci 17:20-26
,2016. Working Memory for Sequences of Temporal Durations Reveals a Volatile Single-Item Store.  Front Psychol 7:1655
,2016. Human ventromedial prefrontal lesions alter incentivisation by reward.  Cortex 76:104-20
,2015. Reduced pupillary reward sensitivity in Parkinson's disease.  NPJ Parkinsons Dis 1:15026
,2015. Reward Pays the Cost of Noise Reduction in Motor and Cognitive Control.  Curr Biol 25(13):1707-16
,2015. Gene therapy for GM1 gangliosidosis: challenges of translational medicine.  Ann Transl Med 3(Suppl 1):S28
,2013. Attention as foraging for information and value.  Front Hum Neurosci 7:711
,2007. Does reward modulate actions or bias attention?  J Neurosci 27(41):10919-21
,Publication list retrieved from NCBI using ImpactPubs
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