Our group aims to apply computational neuroscience to clinical neurology.

Our integrative approach

  • We try to break cognition down into its elementary computational steps, asking what quantities the healthy brain must be using
  • Then we try to understand how these steps map on to brain areas and chemicals, e.g. using brain imaging (fMRI, EEG and MEG)
  • Next we study how neurological diseases, such as stroke or dementia, can disrupt cognition. This needs detailed, quantitative characterisation of the clinical problem by studying how patients perform carefully designed tasks.
  • Finally, we ask whether medications can modify cognition. We are particularly interested in the motivational effects of dopamine and acetylcholine.

Publications

Google Scholar (sorted by impact)

Pubmed (sorted by year)

Grogan JP; Fallon SJ; Zokaei N; Husain M; Coulthard EJ; Manohar SG, 2020. A new toolbox to distinguish the sources of spatial memory error.  J Vis 20(13):6

Grogan JP; Sandhu TR; Hu MT; Manohar SG, 2020. Dopamine promotes instrumental motivation, but reduces reward-related vigour.  Elife 9.

Zokaei N; Sillence A; Kienast A; Drew D; Plant O; Slavkova E; Manohar SG; Husain M, 2020. Different patterns of short-term memory deficit in Alzheimer's disease, Parkinson's disease and subjective cognitive impairment.  Cortex 132:41-50

Codol O; Holland PJ; Manohar SG; Galea JM, 2020. Reward-Based Improvements in Motor Control Are Driven by Multiple Error-Reducing Mechanisms.  J Neurosci 40(18):3604-3620

Manohar SG, 2020. Tremor in Parkinson's disease inverts the effect of dopamine on reinforcement.  Brain 143(11):3178-3180

Al-Diwani A; Handel A; Townsend L; Pollak T; Leite MI; Harrison PJ; Lennox BR; Okai D; Manohar SG; Irani SR, 2019. The psychopathology of NMDAR-antibody encephalitis in adults: a systematic review and phenotypic analysis of individual patient data.  Lancet Psychiatry 6(3):235-246

Tabi YA; Husain M; Manohar SG, 2019. Recall cues interfere with retrieval from visuospatial working memory.  Br J Psychol 110(2):288-305

Fallon SJ; Muhammed K; Drew DS; Ang YS; Manohar SG; Husain M, 2019. Dopamine guides competition for cognitive control: Common effects of haloperidol on working memory and response conflict.  Cortex 113:156-168

Manohar SG; Muhammed K; Fallon SJ; Husain M, 2019. Motivation dynamically increases noise resistance by internal feedback during movement.  Neuropsychologia 123:19-29

Manohar SG; Zokaei N; Fallon SJ; Vogels TP; Husain M, 2019. Neural mechanisms of attending to items in working memory.  Neurosci Biobehav Rev 101:1-12

Ariga R; Tunnicliffe EM; Manohar SG; Mahmod M; Raman B; Piechnik SK; Francis JM; Robson MD; Neubauer S; Watkins H, 2019. Identification of Myocardial Disarray in Patients With Hypertrophic Cardiomyopathy and Ventricular Arrhythmias.  J Am Coll Cardiol 73(20):2493-2502

Nobis L; Manohar SG; Smith SM; Alfaro-Almagro F; Jenkinson M; Mackay CE; Husain M, 2019. Hippocampal volume across age: Nomograms derived from over 19,700 people in UK Biobank.  Neuroimage Clin 23:101904

Fallon SJ; Kienast A; Muhammed K; Ang YS; Manohar SG; Husain M, 2019. Dopamine D2 receptor stimulation modulates the balance between ignoring and updating according to baseline working memory ability.  J Psychopharmacol 33(10):1254-1263

Zokaei N; Board AG; Manohar SG; Nobre AC, 2019. Modulation of the pupillary response by the content of visual working memory.  Proc Natl Acad Sci U S A 116(45):22802-22810

Fallon SJ; Mattiesing RM; Dolfen N; Manohar SG; Husain M, 2018. Ignoring versus updating in working memory reveal differential roles of attention and feature binding.  Cortex 107:50-63

Fallon SJ; Zokaei N; Norbury A; Manohar SG; Husain M, 2017. Dopamine Alters the Fidelity of Working Memory Representations according to Attentional Demands.  J Cogn Neurosci 29(4):728-738

Manohar SG; Finzi RD; Drew D; Husain M, 2017. Distinct Motivational Effects of Contingent and Noncontingent Rewards.  Psychol Sci 28(7):1016-1026

Manohar SG; Akam T, 2017. Cortical areas needed for choosing actions based on desires.  Brain 140(6):1539-1542

Nachev P; Rose GE; Verity DH; Manohar SG; MacKenzie K; Adams G; Theodorou M; Pankhurst QA; Kennard C, 2017. Magnetic Oculomotor Prosthetics for Acquired Nystagmus.  Ophthalmology 124(10):1556-1564

Manohar SG; Pertzov Y; Husain M, 2017. Short-term memory for spatial, sequential and duration information.  Curr Opin Behav Sci 17:20-26

Manohar SG; Husain M, 2016. Working Memory for Sequences of Temporal Durations Reveals a Volatile Single-Item Store.  Front Psychol 7:1655

Manohar SG; Husain M, 2016. Human ventromedial prefrontal lesions alter incentivisation by reward.  Cortex 76:104-20

Manohar SG; Husain M, 2015. Reduced pupillary reward sensitivity in Parkinson's disease.  NPJ Parkinsons Dis 1:15026

Manohar SG; Chong TT; Apps MA; Batla A; Stamelou M; Jarman PR; Bhatia KP; Husain M, 2015. Reward Pays the Cost of Noise Reduction in Motor and Cognitive Control.  Curr Biol 25(13):1707-16

Hayward C; Patel HC; Manohar SG; Lyon AR, 2015. Gene therapy for GM1 gangliosidosis: challenges of translational medicine.  Ann Transl Med 3(Suppl 1):S28

Manohar SG; Husain M, 2013. Attention as foraging for information and value.  Front Hum Neurosci 7:711

Adam RJ; Manohar SG, 2007. Does reward modulate actions or bias attention?  J Neurosci 27(41):10919-21

Publication list retrieved from NCBI using ImpactPubs

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